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CBD And Breast Cancer

In 2011, researchers from the Beth Israel Deaconess Medical Center in Boston discovered the effects of CBD and breast cancer.

In breast cancer, the disease increases the expression of fatty acid amide hydrolase (FAAH), an enzyme that breaks down an important endocannabinoid called anandamide. Anandamide regulates cell proliferation and cell apoptosis; thus, with the increase of FAAH, anandamide is decreased in the body and cannot fight the cancerous cells.

CBD is known to inhibit the function of FAAH and therefore enhance anandamide levels in the body, allowing the endocannabinoid to help kill cancer cells and prevent their production. Also, CBD inhibits the signaling of specific pathways (AKT and mTOR) in cells that decreases proliferation in breast cancer.

Finally, CBD killed cancerous cells by inducing two types of processes: apoptosis and autophagy, both of which are natural, programmed ways to cause the death of cells.

CBD And Brain Tumors

A study researchers at the University of Camerino in Italy found different mechanisms by which CBD could fight brain tumors. CBD induced the death of glioma cells by activating caspases (special enzymes designed to cause cell death) and reactive oxygen species (free radicals).

CBD also seemed to activate the TRPV2 ion channel that allows the cannabinoid to work with other anti-cancer agents in the body to cause further apoptosis of glioma cells. These are likely the mechanisms CBD used to significantly reduce the size of the tumor in the case of the young boy with anaplastic ependymoma in the Dove Clinic study.

According to researchers, the improvement CBD demonstrated in the study’s patients warrants more attention.

The fact that we have been able to document improvement in cancer in few patients strongly supports further studies of CBD-based products in cancer patients who have exhausted standard treatments,- concluded researchers.